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[DEVELOPMENT PROGRESS OF MESENCHYMAL STEM CELLS SENESCENCE].
Published: 11/06/2015, Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Objective
TO summarize the researcn situation or mesenchymal stem cells (MSCs) senescence, including the characteristics and mechanisms of senescence.
Methods
The original articles in recent years about MSCs senescence were extensively reviewed, and comprehensively analyzed.
Results
The senescence of MSCs which manifests as morphological senescence, reduced proliferation and differentiation potential, altered immunoregulation are found during the cultivation in experiment, which profoundly affects clinical application of MSCs. The research about the mechanisms of MSCs senescence includes telomere and telomerase, and stress-mediated injury etc, involving regulation of telomerase, and regulation of signal pathways of p53/p21, P13K/Akt, and Wnt/β-catenin etc.
Conclusion
The further study of senescence mechanisms will help to accelerate the clinical application of MSCs in the future.
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