Telomere Science Library

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about the Nobel-Prize Winning Science of Telomere Biology

[Direct human DNA damage by unfavorable environmental and climatic factors].

aging

senescence

stress

telomere length

Authors: N A NA. Doroshtuk, A Iu AIu. Postnov, A D AD. Doroshtuk, E B EB. Khasanova, N V NV. Konovalova, Iu D IuD. Khesuani, M K MK. Osiaeva, O V OV. Rodnenkov, I E IE. Chazova
Published: 03/25/2015, Terapevticheskiĭ arkhiv

Aim

To study the impact of simulated climatic conditions of the 2010 summer in Moscow on the telomere repeats of chromosomes in human blood cells.

Materials And Methods

The climatic conditions of July-August 2010 in Moscow were simulated at the Medical Technical Complex, Institute of Biomedical Problems, Russian Academy of Sciences. The relative length of the telomeric repeats of blood cell chromosomes from 6 apparently healthy volunteers was measured by quantitative real-time polymerase chain reaction.

Results

These conditions were ascertained to lead to a statistically significant decline in the length of telomere repeats in the terminal portions of chromosomes by 15%.

Conclusion

Environmental changes and abnormal temperature rises may result in oxidative stress accompanied by telomere shortening, which can be, in turn, a factor of premature aging.

PubMed