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about the Nobel-Prize Winning Science of Telomere Biology

Identification of novel interactors of human telomeric G-quadruplex DNA.

genetics

Authors: Bruno B. Pagano, Luigi L. Margarucci, Pasquale P. Zizza, Jussara J. Amato, Nunzia N. Iaccarino, Chiara C. Cassiano, Erica E. Salvati, Ettore E. Novellino, Annamaria A. Biroccio, Agostino A. Casapullo, Antonio A. Randazzo
Published: 02/03/2015, Chemical communications (Cambridge, England)

Abstract

A chemoproteomic-driven approach was used to investigate the interaction network between human telomeric G-quadruplex DNA and nuclear proteins. We identified novel G-quadruplex binding partners, able to recognize these DNA structures at chromosome ends, suggesting a possible, and so far unknown, role of these proteins in telomere functions.

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