Bilal Bawamia, Luke Spray, Vincent K Wangsaputra, Karim Bennaceur, Sharareh Vahabi, Konstantinos Stellos, Ehsan Kharatikoopaei, Emmanuel Ogundimu, Chris P Gale, Bernard Keavney, Rebecca Maier, Helen Hancock, Gavin Richardson, David Austin, Ioakim Spyridopoulos
GeroScience (2023)
Background
Myocardial infarction (MI), or heart attack, is a major medical condition that increases the risk of recurrent cardiovascular...
Singaravelu G, Harley CB, Raffaele JM, Sudhakaran P, Suram A
Background
Cytotoxic T cells (CD8+) play an important role in warding off cells infected with intracellular pathogens and
cancer cells1. The effectiveness of immune response by CD8+ T cells depends on the presence or absence of its
co-receptor, CD28....
Globally, better health care access and social conditions ensured a significant increase in the life expectancy of the population. There is, however, a clear increase in the incidence of age-related diseases which, besides affecting the social and economic sustainability of countries and regions around the globe, leads to a decrease in the individual’s quality of life. There is an urgent need for interventions that can reverse, or at least prevent and delay, the age-associated pathological deterioration.
Small airway remodeling (SAR) is a key phenomenon of airflow obstruction in smokers, leading to chronic obstructive pulmonary disease (COPD). SAR results in an increased thickness of small airway walls, with a combination of peribronchiolar fibrosis with increased fibrous tissue and accumulation of mesenchymal and...
Owing to a dramatic increase in average life expectancy and the Family Planning program of the 1970s - 1990s, China is rapidly becoming an aging society. Therefore, the investigation of healthspan-extending drugs becomes more urgent. Astragalus membranaceus (Huangqi) is a major medicinal herb that has been commonly used in many herbal formulations in the practice of traditional Chinese medicine (TCM) to treat a wide variety of diseases and body disorders, or...
Salvador L, Singaravelu G, Harley CB, Flom P, Suram A, Raffaele JM.
TA-65 is a dietary supplement based on an improved formulation of a small molecule telomerase activator that was discovered in a systematic screening of natural product extracts from traditional Chinese medicines. This study summarizes the findings on telomere length...
Telomere attrition and corresponding cellular senescence of the retinal pigment epithelium contribute to the changes of age-related macular degeneration. Activation of the enzyme telomerase can add telomeric DNA to retinal pigment epithelium chromosomal ends and has been proposed as a treatment for age-related macular degeneration. We report the use of a small molecule, oral telomerase activator (TA)-65 in early macular degeneration. This study, focusing on early macular degeneration, provides a...
By T.A. Sciences ®Harley CB, Liu W, Blasco MA, Vera E, Andrews WH, Briggs LA, Raffaele JM. Rejuvenation Research. February 14, 2011 (1): 45-56.
This one year human study showed improvements in telomere length and immune system biomarkers for people taking TA-65® capsules. The study confirmed TA-65®'s previously noted health effects...
By T.A. Sciences ® | 14th November 2013
An observational study published in the October 2013 issue of Rejuvenation Research reports on observed changes in metabolic and cardiovascular health markers in people who took TA-65MD® nutritional supplements for one year.
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By T.A. Sciences ®
Molgora B, Bateman R., Sweeney G., Finger D., Dimler T., Effros R.B., Valenzuela H.F., Cells Journal. 2013 January 14: ISSN 2073-4409
This human study demonstrates that TA-65MD® nutritional supplements increase telomerase activity and proliferation in human CD4 and CD8 T cells. It highlights the importance of Telomerase...
By T.A. Sciences ®
de Jesus BB, Schneeberger K, Vera E, Tegera A, Harley CB, Blasco MA. Aging Cell. 2011 August; 10(4): 604-621.
This animal study looked at the effects of TA-65® and confirmed their mechanism of action, long-term effects, and safety.
Study Model: To confirm mechanism of action (through Telomerase Activation),...
By T.A. Sciences ®
In the largest and most diverse study of aging to date, telomere length is being analyzed as a marker for age-related conditions. This genomic project, Genetic Epidemiology Research on Adult Health and Aging (GERA), aims to increase understanding of the genetic basis for a host of...
By T.A. Sciences ®
Jaskelioff M., Muller F.L., Paik J.H., Thomas E., Jiang S., Adams A.C., Sahin E., Kost-Alimova M., Protopopov A., Cadiñanos J., Horner J.W., Maratos-Flier E., Depinho R.A. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.
Nature. 2011;469(7328):102-106.
According to a study published in the January 2011 issue of...